ANTIBIOTIC POTENCY TESTS

BACKGROUND:

AMS Laboratories are able to perform antibiotic potency testing by the bioassay method. Antibiotic potency is estimated by comparing the inhibition of growth of sensitive micro-organisms produced by known concentrations of the antibiotic being examined against a reference standard substance.  The test is performed on raw materials and finished products to confirm the antibiotic activity meets specifications.

PRINCIPLE OF TEST:

All test methods are based on the European and British Pharmacopeia: Biological assay of antibiotics, BP Appendix XIV A (Ph. Eur. method 2.7.2)

This is a large-plate format procedure where test and standard preparations are loaded into wells in a randomized latin square arrangement before incubation and reading  the zones of inhibition.

List of methods/antimicrobials available:

 Amphotericin B

Bacitracin

Bleomycin

Colistin                                                                   antibiotic potency tests

Colistimethate

Dihydrostreptomycin

Erythromycin

Framycetin

Gentamicin

Kanamycin

Neomycin

Netilmicin

Nystatin

Polymyxin B

Rifamycin

Spiramycin

Streptomycin

Tobramycin

Tylosin

Vancomycin

We can also perform Antimicrobial Activity Tests such as the

 Minimum Inhibition Concentration (MIC) Test

Minimum Bactericidal Concentration (MBC) Test

Minimum Kill Concentration ( MKC) Test

Zone of Inhibition (ZOI) Test

 

SAMPLE REQUIREMENTS and TURNAROUND TIMES:

 AS these will vary with the type of product and study required, please contact the laboratory to discuss your needs.